Planta Med 2005; 71(4): 362-363
DOI: 10.1055/s-2005-864104
Letter
© Georg Thieme Verlag KG Stuttgart · New York

C-Glycosylflavones from the Aerial Parts of Eleusine indica Inhibit LPS-Induced Mouse Lung Inflammation

Giany O. De Melo1 , Michelle F. Muzitano1 , Alexandre Legora-Machado2 , Thais A. Almeida2 , Daniela B. De Oliveira1 , Carlos R. Kaiser3 , Vera Lucia G. Koatz2 , Sônia S. Costa1
  • 1Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • 2Departamento de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • 3Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Further Information

Publication History

Received: July 23, 2004

Accepted: December 12, 2004

Publication Date:
27 April 2005 (online)

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Abstract

The infusion of aerial parts (EI) of Eleusine indica Gaertn (Poaceae) is used in Brazil against airway inflammatory processes like influenza and pneumonia. Pre-treatment with 400 mg/kg of crude extract inhibited 98 % of lung neutrophil recruitment in mice exposed to aerosols of lipopolysaccharide (LPS) from Gram-negative bacteria, in a dose-dependent manner. At 400 μg/kg, schaftoside (6-C-β-glucopyranosyl-8-C-α-arabinopyranosylapigenin) and vitexin (8-C-β-glucopyranosylapigenin), isolated from EI, inhibited 62 % and 80 % of lung neutrophil influx, respectively. These results may justify the popular use of E. indica against airway inflammatory processes.

References

Dr. Sônia S. Costa

Núcleo de Pesquisas de Produtos Naturais

Universidade Federal do Rio de Janeiro

21 941 590 Rio de Janeiro

RJ

Brazil

Email: sscosta@nppn.ufrj.br